Retinopathy of prematurity: oxygen dogma challenged.

Retinopathy of prematurity: oxygen dogma challenged.

Oxygen free radicals and retinopathy of prematurity.

Current Concepts of Oxygen Management in Retinopathy of Prematurity

Retinopathy of prematurity (ROP) is a potentially blinding disorder in premature infants. The underlying pathophysiology is incompletely understood, limiting the prevention and treatment of this devastating condition. Current therapies are directed toward management of aberrant neovascularization thought to result from retinal ischemia in the developing preterm retina. The molecular mediators i...

[Retinopathy of prematurity and oxygen therapy: a changing relationship].

INTRODUCTION The use of oxygen was implemented in neonatal practice in the absence of any randomized studies. The dose was (and still is in some places) not measured well. Additionally, the newborn’s oxygenation levels were not measured routinely until Arterial Blood Gases (ABG’s), capillary samples, transcutaneous PO2 (TcPO2) and, more recently, monitoring of oxygen saturation by pulse oximetr...

Retinopathy of Prematurity

The incidence of ROP varies with birth weight but it has been reported to be approximately 50-70% in infants whose weight is less than 1250g at birth. The more premature the infant, the more likely ROP is to develop [1]. Furthermore, an observational study from United Kingdom found that the birth weight of infants from highly developed countries was 737-763g compared with 903-1527g in less-deve...